Self-questionnaire to assess patient’s preferences for participation in phase I clinical trials
نویسندگان
چکیده
منابع مشابه
Phase I clinical trials
Phase I trials are conducted to find a dose to use in subsequent trials. They provide data on the rate of adverse events at different dose levels and provide data for studying the pharmacokinetics and pharmacology of the drug. Dose-finding studies that involve therapies with little or no toxicity often enroll healthy volunteers and usually have a control group. Trials in oncology and other life...
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BACKGROUND Inclusion of minorities in clinical research is an essential step to develop novel cancer treatments, improve health care overall, understand potential differences in pharmacogenomics and address minorities' disproportionate cancer burden. However, Latinos and other minority groups continue to be critically underrepresented, particularly in early-phase clinical trials (EPCTs). The ob...
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BACKGROUND To reduce the duration and overall costs of cardiovascular trials, use of the combined endpoints in trial design has become commonplace. Though this methodology may serve the needs of investigators and trial sponsors, the preferences of patients or potential trial subjects in the trial design process has not been studied. OBJECTIVE To determine the preferences of patients in the de...
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BACKGROUND Many cancer patients in phase I clinical trials are treated at doses of chemotherapeutic agents that are below the biologically active level, thus reducing their chances for therapeutic benefit. Current phase I trials often take a long time to complete and provide little information about interpatient variability or cumulative toxicity. PURPOSE Our objective was to develop alternat...
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PURPOSE/OBJECTIVES To reveal the decision-making process in patients considering participation in cancer phase I clinical trials. DESIGN Grounded theory approach. SETTING Cancer center in a metropolitan area of Tokyo, Japan. PARTICIPANTS 25 patients with cancer, including individuals who ultimately declined to participate in a phase I trial. METHODOLOGIC APPROACH Semistructured intervie...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2018
ISSN: 0923-7534
DOI: 10.1093/annonc/mdy047.088